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Search Results for " antihypertensive effect "

14

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7808	Alacepril Cetapril,阿拉普利,DU-1219	RAAS	Endocrinology/Hormones
	Alacepril (DU-1219) 是一种具有口服活性血管紧张素转换酶 (ACE) 抑制剂，具有长效抗高血压作用。
T0088	Urapidil hydrochloride Urapidil HCl,盐酸乌拉地尔	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Urapidil hydrochloride (Urapidil HCl) 是α1-肾上腺素受体拮抗剂和5-HT1A 受体激动剂。
T23044	N,N'-Dicyclohexylurea DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲	Epoxide Hydrolase	Metabolism
	N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。
T1007	Nanofin 那诺芬,Lupetidine,Lupetidin,2,6-Lupetidine,2,6-Dimethylpiperidine,Naniopinum	AChR	Neuroscience
	Nanofin (Lupetidine) 是一种神经性阻断药，具有降压作用，可用于轻中度高血压的研究。
T19286	Dixyrazine UCB 3412	Others	Others
	Dixyrazine（UCB 3412）具有短暂的降压作用，可预防注射硫酸鱼精蛋白引起的脑水肿，可用于研究与神经系统相关的疾病。
T31777	Fenquizone M.G. 13054	Others	Others
	Fenquizone (M.G. 13054) 是一种噻嗪样利尿剂，具有慢性抗高血压作用。Fenquizone 可用于水肿和高血压的研究。
T2531L	Eprosartan KF-108566J free base,Teveten	RAAS	Endocrinology/Hormones
	Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂，对AT1受体亚型具有高亲和力，可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
T12866	SCH 42495 racemate SCH 42495 (racemate)	Others	Others
	SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.
T12641	(R)-SCH 42495	Others	Others
	(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active inhibitor of neutral metalloendopeptidase (NEP), with antihypertensive effect.
T72001	CB096
	CB096 is a novel inhibitor of RAN translation. specifically binds to a repeating 1 × 1 GG internal loop structure, 5'CGG/3'GGC, that is formed when r(G4C2)exp folds, also acting as a potent vasorelaxant agent, showing antihypertensive effect.
T26452	A 80b A80b,A-80b
	A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-8
T61983	Trichlormethiazide sodium
	Trichlormethiazide sodium 是口服有效的噻嗪类利尿剂，显示降压活性。在急性肾功能衰竭大鼠中，Trichlormethiazide sodium 可增加尿量、Na 和 K 排泄，并有改善肌酐清除率 (CCRE)。
T78657	Azilsartan mepixetil potassium QR-01019K
	Azilsartan mepixetil potassium (QR-01019K)，是一种高效安全的血管紧张素 II 受体拮抗剂，展现出卓越的持久降压效应以及显著且持续的降心率功能，有望用于治疗高血压、慢性心力衰竭和糖尿病肾病。
T37496	Alamandine
	Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effe...

化合物

Cat.No: T7808

Synonym: Cetapril,阿拉普利,DU-1219

Target: RAAS

Urapidil hydrochloride

Cat.No: T0088

Synonym: Urapidil HCl,盐酸乌拉地尔

Target: 5-HT Receptor, Adrenergic Receptor

N,N'-Dicyclohexylurea

Cat.No: T23044

Synonym: DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲

Target: Epoxide Hydrolase

Cat.No: T1007

Synonym: 那诺芬,Lupetidine,Lupetidin,2,6-Lupetidine,2,6-Dimethylpiperidine,Naniopinum

Target: AChR

Cat.No: T19286

Synonym: UCB 3412

Target: Others

Cat.No: T31777

Synonym: M.G. 13054

Target: Others

Cat.No: T2531L

Synonym: KF-108566J free base,Teveten

Target: RAAS

SCH 42495 racemate

Cat.No: T12866

Synonym: SCH 42495 (racemate)

Target: Others

Cat.No: T12641

Target: Others

Cat.No: T72001

Cat.No: T26452

Synonym: A80b,A-80b

Trichlormethiazide sodium

Cat.No: T61983

Azilsartan mepixetil potassium

Cat.No: T78657

Synonym: QR-01019K

Cat.No: T37496

Cat. No.	Product Name	Target	Signaling Pathways
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。
TN6007	Serpentinine
	Serpentinine may have antihypertensive effect.
TN5645	Isomartynoside
	Isomartynoside has inhibition against the angiotensin converting enzyme (ACE) activities, the IC 50 value is 505±26.7μg/ml, it may have antihypertensive effect. Isomartynoside also shows obvious anti-fatigue activity.
TN4431	Leucosceptoside A	RAAS; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones
	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidase. Leucosceptoside A has antihypertensive effect, it shows angiotensin converting enzyme (ACE)

天然产物

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Cat.No: TN6007

Cat.No: TN5645

Leucosceptoside A

Cat.No: TN4431

Target: RAAS, PKC

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